The acceleration of autonomous technologies and systemic disruptions is eroding the assumption that risk can be predicted or controlled. For the C-suite, this necessitates a shift from planning for a single future to leading through deep uncertainty. Success requires cultivating foresight, preserving optionality, and building organizations that sense change, adapt, and maintain autonomic resilience. Anticipatory leaders who embrace uncertainty as a structural condition, rather than a temporary disruption, can move beyond legacy assumptions to achieve systemic agility.